The Power of Lion's Mane
What the research says about this medicinal mushroom's effect on nerves, cognition and beyond
Lion's mane (Hericium erinaceus) is one of the most researched medicinal mushrooms in the world, studied for its effects on the brain, the nervous system and beyond. A 2026 peer reviewed laboratory study looked specifically at what its extract does to canine cancer cells.
Supports nerve growth and cognitive function
Lion's mane's bioactive compounds, erinacines and hericenones, are studied for their ability to stimulate nerve growth factor, support the regeneration of damaged nerve tissue, and act as antioxidants and anti inflammatories. This research is why lion's mane is included in Better Hydration, for cognitive and nervous system support alongside physical recovery.
This research draws mainly on human and other mammalian studies of these compounds. The mechanisms described are conserved across species but have not been confirmed in dogs specifically.
Slowed cancer cells, left healthy cells largely alone
There is more specific research too. In a 2026 laboratory study, researchers applied a lion's mane extract to two canine mammary cancer cell lines. The extract slowed proliferation, triggered apoptosis (programmed cell death) in the cancer cells, and reduced their ability to migrate and invade, a key early step in metastasis. Healthy dog cells were far less affected by the same extract.
This is cell culture research, not a treatment: early evidence the study authors say warrants further investigation, not a cure.
Already in the routine
Lion's mane is one of six functional ingredients in Better Hydration, alongside goat's milk, nutritional yeast, MCTs, collagen and ginseng. Mixed with water, it supports rapid hydration and recovery while contributing the nerve and cognitive support described above, particularly for working, ageing or highly active dogs.
Sources
1. Contato AG, Conte-Junior CA. Lion's Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential. A Narrative Review. Nutrients. 2025;17(8):1307.
2. Jermnak, et al. Synergistic apoptotic and epithelial-mesenchymal transition-inhibitory effects of Hericium erinaceus extract in canine mammary cancer cell lines. Veterinary World. 2026.
Reference 2 is an in vitro (cell culture) study using canine cells and does not establish a treatment for dogs with cancer. Better Hydration and Better Every Day are complementary feed supplements, not intended to diagnose, treat or cure any condition. Speak to your vet about any health concern, including a cancer diagnosis.